在exon 1中插入了Frt-flanked诺卡因抗性基因座和一个终止密码子。通过表达Flpe重组酶,暂时移除了诺卡因基因座。通过流式细胞术和小鼠脾自然杀细胞(NK细胞)的免疫印迹分析,确认了基因失活。NK细胞上其他SLAM家族成员的表达未受影响。(来源:J:145969)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入,基因内删除
--
1
--
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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