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中文
CC10-rtTA-hGH构建包含了CC10启动子、反式四环素转录激活因子(rtTA)和人类生长激素(hGH)的内含子和poly(A)序列。pTRE-Nos2-SV40构建含有聚合四环素响应元件(tet-O)、基本的CMV启动子、小鼠Nos2的cDNA以及SV40的内含子和poly(A)信号。这两个构建物在受精卵中一起注射，得到了双阳性克隆动物。在有doxycycline(多西环素)存在时，rtTA能与tet-O结合，VP-16转录激活因子激活LIF基因的转录。在无dox时，rtTA的结合量极低，基因转录也仅处于较低水平。(来源：J:131101)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
