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中文
在Ext1基因的基因组片段中，上游插入了一个反向的loxP位点。然后，这个带有Ext1基因的片段被克隆到一个载体中，载体的前方有正向的loxP标记的Neo抗性基因。线性化的靶向载体通过电穿孔法导入R1 ES细胞。通过Cre介导的重组，这个等位基因会发生Exon2的反转，从而破坏Ext1的功能。(来源：J:145524, J:157599)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
