一段包含启动子区域、外显子1和外显子2的1.1千碱基DNA被替换成在已经含有目标等位基因Hbb-bh1的ES细胞中带有floxed PGK-hygro筛选元件。随后,这两个基因的筛选元件通过与CMV-cre转基因小鼠杂交来剔除。这个等位基因仅与Hbb-bh1基因同时存在。(来源:J:145362)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入,基因内删除
--
1
5
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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