Gli2^tm1Blnw

A floxed neomycin cassette was inserted upstream of the last exon, part of which was replaced with corresponding mouse cDNA sequences containing Ser-Ala mutations in the codons for the first four protein kinase A sites (S789A, S805A, S817A and S848A). The neomycin was left in place because of the increased lethality of heterozygotes that occured when it was removed. (J:145182)