编码23到69位氨基酸的外显子被一个包含splice接受器和修改过的部分cDNA的构建替换,该cDNA编码p80剪接形式,其中替换了185和198两个酪氨酸(phosphorylation位点)为苯丙氨酸。通过瞬时Cre表达,去除了含neo标记的选择性克隆 cassette(来源:J:145031)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S4/SvJaeSor
Targeted
插入,基因内删除
--
1
1
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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