Pold1小鼠与表达Tg(Sycp1-cre)1Uchi转基因小鼠杂交。Cre在生殖细胞中的表达会去除SV40的剪接/polyadenylation信号和诺卡因抗性基因座。由此产生的等位基因编码一种3'-5'核酸外切酶活性缺失的蛋白质。(来源:J:144992)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count