将人类AGT基因的完整13.5kb序列,来自一个AA等位基因的个体,插入到BK4胚胎干细胞(Hprt基因座)的上游。AA等位基因在以下位置含有特定的核苷酸:-6A, -20A, -217A, -532T, -793A, -1074T。插入载体还恢复了BK4 ES细胞中缺失的Hprt启动子和外显子区域。(来源:J:143791)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入
--
1
2
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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