一只含Pdgfra基因的鼠标PAC克隆(RPCI21-546M3)被改造,通过在exon 2插入了tamoxifen诱导型Cre重组酶基因,同时伴有Frt标签的氯霉素选择性载体,随后这个载体被去除了。产生了11个后代,但只有2个符合预期地表达了Cre。更强表达的转基因品系被用作代表(来源:J:144591)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Not Specified
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51

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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