一段exon 2被设计成目标替换,用一个包含-galactosidase基因和诺卡因抗性基因的 cassette,导致下游序列移出阅读框。通过从小肠上皮细胞中提取的蛋白质样品进行免疫印迹分析,确认了基因失活。邻近的Casp1和Casp4 caspase基因的表达在这些小鼠中没有受到影响。(来源:J:144912)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S1/SvImJ
Targeted
基因内删除
--
1
--
6

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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