一段35.5kb的巴米希林(Ba mHI)基因组片段,包含了人类的SMN2启动子和基因(来自基因克隆PAC215P15),被注入到了FVB/N雌性鼠的卵母细胞中。通过这种方式,我们成功建立了转基因的SMN2小鼠,这些小鼠来自46号杂交群,它们体内含有两个拷贝的转基因。(来源:J:144853)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
FVB/N
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1
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
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Year
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