这个突变是在对一个ENU诱变雄性小鼠G3代进行TLR信号通路筛选时发现的。突变发生在基因(Genbank: NM_011604)的第1454位碱基,导致从异亮氨酸变为丝氨酸,位置在蛋白质的第441位(I441T)。(来源:J:144168)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6J
Chemically induced
单点
隐性
1
--
--

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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