编码催化区域的外显子通过小鼠的生殖细胞遗传学手段,通过Cre介导的重组被去除。在杂合组织中,通过 Western Blot 分析,蛋白表达减少了50%。(来源:J:144055)
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The exon encoding the catalytic domain was removed by germ line, cre-mediated recombination. Protein expression is reduced 50% in heterozygous tissues as determined by western blot analysis. (J:144055)