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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
基因编辑小鼠
Tcrb
tm5Slek
Alias:
Jbeta1
sigma
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基础信息
表型特征
文献报道
这种ES细胞包含Tcrbtm1Slek,其中Dbeta2-Jbeta2基因簇被一个LoxP位点替换,额外的目标使得产生了一个只保留一个Dbeta和Jbeta基因片段的TCRb等位基因。六份Jbeta1基因段中的五份(Jbeta1.2-1.6)被替换成一个LoxP引导的诺卡因载体。随后,通过Cre介导的重组移除了诺卡因抗性基因。这个等位基因因此缺失了Dbeta2-Jbeta2基因簇的2kb,以及五份Jbeta1基因段的1.5kb。因此,所有基于这个等位基因组装的TCRβ链都使用Dbeta1和Jbeta1.1基因片段。(来源:J:143738)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
3829440
Not Specified
Targeted
Insertion, Intergenic deletion
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1
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
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