在SmaI酶切位点上游插入了一个floxed neo选择 cassette,然后在exon 9下游插入了一个额外的loxP位点。通过基因组PCR确认了靶向的正确性。LoxP标记的序列(floxed)编码了ADAR1诱导型形式的707-870位氨基酸残基,包括编辑活性所必需的区域(J:87715)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入
--
1
4
19

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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