在内皮或β亚型中,插入了一个带有停用密码子的neo质粒表达座,它位于内含子9,并在exon 8插入了终止密码。这导致了D3段的不完整和错误折叠。通过与Tg(ACTB-cre)2Mrt小鼠杂交,以剔除floxed neo元件。(来源:J:142946)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S1/Sv-Oca2+ Tyr+ Kitl+
Targeted
插入
--
1
39
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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