在exon 3的上游插入了loxP位点,接着是frt标签的neo cassette,包含第二个loxP位点,并在exon 3的3' UTR中插入了人类碱性磷酸酶基因。定量RT-PCR结果显示,纯合胚胎中RNA表达水平有所下降。(来源:J:141834)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count