在exon 3的上游插入了loxP位点,接着是frt标签的neo cassette,包含第二个loxP位点,并在exon 3的3' UTR中插入了人类碱性磷酸酶基因。定量RT-PCR结果显示,纯合胚胎中RNA表达水平有所下降。(来源:J:141834)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S7/SvEvBrd-Hprt1b-m2
Targeted
插入
--
1
7
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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