将融合的人类MYC和ESR1(ERT2)序列,前有带有三重polyadenylation序列的floxed neo cassette,后接有IRES-EGFP,插入到ROSA定位点。这种融合产物的表达只有通过Cre介导去除neo cassette及其polyadenylation序列后才能实现。通过小鼠的生殖细胞中Cre介导的重组,移除neo cassette和三重polyadenylation序列,以驱动融合基因和EGFP的表达。(来源:J:142030)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Not Specified
Targeted
插入
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6

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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