exon 3内的编码区域被一个带有floxed neo cassette的替换,通过小鼠的生殖细胞(germ line)和cre介导的重组来消除neo cassette。蛋白表达缺失通过E8.5至E9.5时期胚胎整体提取物的western blot分析来确认(来源:J:142039)。
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count