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中文
基因座Exon 4被设计了一个突变，导致第227位的天冬氨酸替换为赖氨酸（D227K）。下游插入了去氨甲基化新霉素抗性基因座，随后通过和携带Cre转基因小鼠杂交来移除。在纯合小鼠激活的CD4+ T细胞表面，突变蛋白表达水平与野生型小鼠内源性蛋白相似，预测这会干扰CD8核心受体复合物的结合。（来源：J:142087）
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
