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中文
在第3个内含子中插入了loxP位点和frt引导的neo抗性元件，同时在内含子6a中也插入了一个loxP位点。通过定向杂交，这些经过精确修饰的实验鼠与Gt(ROSA)26Sor小鼠交配，以去除选择性元件。随后，它们与一个未指明的EIIa-cre转基因小鼠杂交，以删除4到6a号外显子。免疫印迹分析证实了蛋白产物的缺失。(来源：J:141583)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
