Atg16l1^{Gt(BC0122)Wtsi}

A gene-trap vector containing a splice acceptor followed by a beta-geo cassette disrupted the gene locus by inserting within the intronic region after exon 6. Protein expression of both the alpha and beta isoforms of the gene product were 23-37% of wild-type as determined by immunoblots of ileal lysates from homozygous mice. This is a hypomorphic allele. (J:141419)