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在第13个内含子插入了一个floxed neo cassette，然后通过同源重组在第14号外显子插入了D486A突变。随后，通过体内Cre介导的重组移除了neo cassette。D486A突变产生了非活化激酶的蛋白质。 Western blot结果显示，纯合胚胎和MEFs中蛋白质表达量减少了超过50倍。(来源：J:141095)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
