这个等位基因在致癌形式的基因(p.G12D突变)内有一个FRT-STOP-FRT的 cassette,位于内含子1。在引入增强型的Flp(FLPe)或优化的鼠源FLP(FLPo)重组酶之前,由于转录上的STOP cassette,它不表达。引入重组酶后,STOP cassette被去除,导致突变的Kras转录本和蛋白的表达。(来源:J:140469)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6
Targeted
插入
--
1
37
24

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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