从一个I-Ab限制、针对β-gal特异的CD4+ T细胞克隆中分离出了RNA。Tcra和Tcrb基因的可变区被克隆到TCR cassette载体中,然后一起注入到受精卵中。转基因小鼠产生了能识别LacZ基因产物肽的T细胞。(来源:J:140121, J:140160)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count