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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
基因编辑小鼠
Nct1/Nct2
tm1Nbh
Alias:
Nct1
tm1Nbh
Nct1/2
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基础信息
表型特征
文献报道
在两个基因座的整个编码序列被一个LoxP引导的诺姆西林选择座替换后,这两个基因座的皮质RNA(piRNA)在纯合雄性小鼠的睾丸RNA中通过实时PCR检测不到。此外,删除区域上游的皮质RNA,如piR-135965,最多7kb,以及下游的8kb区域(piR-111581),在这些雄性纯合个体的睾丸中显著减少。这些piRNA中,针对L1转座子的表达在这些小鼠的睾丸中有所增加,L1转座子是这些皮质RNA的一部分。(来源:139921)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
3811743
(C57BL/6J x 129X1/SvJ)F1
Targeted
Insertion, Intergenic deletion
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1
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
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