Tg(Igk*G)G07Dgs

Vk167/PEPS is an Igk transgene with a truncated region upstream of the promoter. The Igk (immunoglobulin kappa) sequence was further modified through the insertion, near the 3' end of the variable region of Igk, of 5 tandem repeats of a 20-bp adenine/thymine (A/T) fragment in the same orientation as the insert in the TgA line but includes a single guanine:cytosine (G:C) base pair in the central repeat. In this "TgG" line, the cytosine was placed on the 3'->5' strand of the DNA. (J:139793)