Bpnt2^{Gt(RST634)Byg}

Insertion of the gene-trap vector in the first intron encodes the first exon of Impad1 gene fused to beta-galactosidase. It is predicted to express a truncated mutant protein that would contain only 1 of 13 catalytically conserved residues. Western blot and biochemical analyses confirmed homozygous mice are deficient for functional enzyme. (J:139706)