除了靠近膜的arginine外,整个67个氨基酸的胞质区被删除。插入了一个紧接着的第二个arginine密码子以及两个终止密码子。下游的Neo cassette通过在靶向的ES细胞中表达的Cre诱导暂时去除,外分泌域和跨膜域的表达正常。(来源:J:138731)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
插入
--
1
--
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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