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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
基因编辑小鼠
Igh-J
tm3(3H9-VDJ*)Mwg
Alias:
3H9H/56R/76R
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基础信息
表型特征
文献报道
内源性DQ52和所有四个重链J区元件被替换为一个重组的重链V3H9基因,编码抗dsDNA抗体的H链,带有两个氨基酸替换。这些替换是在第56位的天冬氨酸替换为arginine(A56R)以及第76位的serine替换为arginine(S76R)。构建中还包含了一个诺卡因抗性基因,位于上游。(J:126940)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
3808989
129P2/OlaHsd
Targeted
Insertion, Intergenic deletion
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--
--
2
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
No Data Found!
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