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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
基因编辑小鼠
Fmr1
tm1.2Cidz
Alias:
Fmr1 KO2
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基础信息
表型特征
文献报道
通过将具有第一编码外显子敲除的Fmr1小鼠与在生殖细胞中表达Cre重组酶的 mice (Tg(CAG-cre)13Miya) 杂交,创造出了一个生殖细胞的隐性突变。基因失活通过免疫印迹分析在大脑和睾丸中缺乏蛋白质表达来验证。(来源:J:108008)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
3808885
129P2/OlaHsd
Targeted
基因内删除
--
1
5
47
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
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