1-3号外显子被新农霉素抗性基因 cassette 替换。Northern blot 检测在纯合小鼠中未发现 mRNA,而睾丸提取物的 Western blot 也未检测到蛋白质。(来源:J:138122)
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Exons 1-3 were replaced by a neomycin cassette. mRNA was not detectable in homozygous mice by Northern blo analysis and protein was not detectable by Western blo in extracts of testes. (J:138122)