所有的编码外显子都被替换了为一个neo cassette。通过在血浆提取物中进行 Western blot 分析,证实了没有蛋白质表达(来源:J:138581)
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All the coding exons were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on plasma extracts. (J:138581)