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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
基因编辑小鼠
Drosha
tm1.1Litt
Alias:
Drosha
delta
Drosha
del
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基础信息
表型特征
文献报道
使用了一种靶向载体,将一个含loxP切割位点的诺卡因抗性基因座插入到了基因的第8内含子,并在第9内含子增加了一个loxP位点。这些小鼠与C57BL/6背景的EIIa-Cre纯系杂交,该纯系能删除第9外显子(以及诺卡因基因座)。(来源:J:138683)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
3806089
129P2/OlaHsd
Targeted
插入,基因内删除
--
1
1
5
Phenotypes
Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes
References Literature
Title
PMID
Journal
Year
IF
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