使用了一种靶向载体,将一个含loxP切割位点的诺卡因抗性基因座插入到了基因的第8内含子,并在第9内含子增加了一个loxP位点。这些小鼠与C57BL/6背景的EIIa-Cre纯系杂交,该纯系能删除第9外显子(以及诺卡因基因座)。(来源:J:138683)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
--
1
1
5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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