构建中包含人IL6基因和兔β-球蛋白序列,由小鼠H-2Ld启动子驱动,这个转基因元件被注入了C57BL/6小鼠的受精卵。通过ELISA检测,人IL6蛋白在血清中被发现。mRNA则在脾脏、淋巴结、胸腺、心脏、肺、肝、肾和肠道中检测到,但大脑组织中未见。(来源:J:40405, J:138762)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count