这个转基因包含了野生型人类α-synuclein的cDNA和小鼠Prnp基因的启动子,包括带有内含子的5'非编码区和3'非编码序列。转基因表达在大脑皮层、脊髓和小脑中被检测到。建立了7、12和20号线(来源:J:76657)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6 x C3H
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1
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5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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