使用MICE载体插入了loxP位点,一个位于Ifitm5基因的着丝粒区,另一个位于Ifitm6基因的端粒区。在胚胎干细胞中短暂表达Cre,以去除这两基因之间大约120kb的基因组区域,包括Ifitm5、Ifitm2、Ifitm1、Ifitm3和Ifitm6。(来源:J:137940)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129P2/OlaHsd
Targeted
Intergenic deletion, Intragenic deletion
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7

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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