在exon 2的上游插入了一个loxP位点,exon 2包含了整个开放阅读框,然后在exon 2下游插入了一个带有5' loxP位点的frt-flanked neo cassette,后面跟着lacZ cassette。通过遗传背景的germ line,使用flp介导的重组来去除neo cassette,使得exon 2被标记为可删除,而lacZ cassette保持不变。这段信息出自文献(J:137951)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129/Sv
Targeted
插入
--
1
6
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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