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中文
构建了一个970千碱基的人造酵母染色体(YAC)，它来自人类生殖细胞的免疫球蛋白重链基因簇。这个YAC包含了66个V重链基因段，所有6个J基因段，30个D基因段，Cμ、Cδ和Cγ2的恒定区，下游的小鼠增强子元件，以及一个诺卡因抗性基因。通过Southern blot检测，确认YAC插入未发生任何重组。转基因小鼠显示出表达人类重链免疫球蛋白。(文献引用：J:70620, J:139719)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
