将含小鼠Abca1(ATP结合盒亚家族A(ABC1)成员1)基因的转基因构建,通过小鼠Prnp(朊蛋白)启动子的控制,注入了去核的B6CBAF1卵子中。随后建立了F0代(Founder line E)。这些F0代小鼠皮质中Abca1的表达比野生型高出6倍。 Western blot分析显示,转基因表达在大脑总组织、肾、睾丸和肌肉中都很高。(来源:J:131400)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6 x CBA)F1
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1
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2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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