Gfap启动子被用来在大脑中驱动Il6的表达。创建了G369、G16和G167等几条转基因小鼠线。G16的祖先整合了转录基因,同时还有另一个转录因子lacZ,它在Gfap的调控下表达。而G26和G36的祖先则不包含这种额外的转录元件。这条线中包含了四拷贝的IL-6转录基因。(来源:J:125549)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6J x SJL)F1
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1
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25

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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