通过在9号染色体qA3区域的AB124611和Carm1之间插入携带5' loxP位点的转录基因,利用逆转录病毒的插入方式创建了TIGRE位点。随后,通过Cre介导的 cassette exchange,先引入了一个带有5' loxP位点的Apoe基因,这个基因是可诱导且可敲除的。(来源:J:136987)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129S1/Sv-Oca2+ Tyr+ Kitl+
Targeted
插入
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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