在exon 2的上游插入了lox P座,然后在exon 4的下游插入了一个带有5' loxP座的frt-flanked neo cassette。通过遗传背景的germ line,使用flp介导的重组来去除neo cassette,使得exons 2到4都被留下了lox P标记。(来源:J:136451)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count