通过在5'端插入LoxP位点,3'端包含Frt-PGK-neomycin-Frt-LoxP表达座,构建了一个靶向载体。随后,这些带有内切位点的转基因小鼠与CAGG-Flpe转基因小鼠杂交,以产生可遗传的突变型(Floxed allele)。来源:(J:137185)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
插入
--
1
1
5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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