将胸苷激酶定向插入C57BL/6J小鼠源性染色体5的Dpp6位点(位于v6.4 ES细胞系中),随后通过400 Gy伽马射线照射、FIAU筛选,并将细胞注射到C57BL/6J的囊胚中。这个操作导致的删除区域包括D5Mit348至D5Mit389,不包括Wolf-Hirschhorn综合症的关键区域。(来源:J:67077)
Basic Information
(C57BL/6J x 129S4/SvJae)F1
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count