将胸苷激酶定向插入C57BL/6J小鼠源性染色体5的Dpp6位点(位于v6.4 ES细胞系中),随后通过400 Gy伽马射线照射、FIAU筛选,并将细胞注射到C57BL/6J的囊胚中。这个操作导致的删除区域包括D5Mit348至D5Mit389,不包括Wolf-Hirschhorn综合症的关键区域。(来源:J:67077)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6J x 129S4/SvJae)F1
Radiation induced
基因间区删除
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--
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2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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