将胸苷激酶定向插入C57BL/6J小鼠源性染色体5的Htt位点(v6.4 ES细胞系),随后通过400 Gy伽马射线照射、FIAU筛选,并将细胞注射到C57BL/6J的囊胚中。这个操作涵盖了Wolf-Hirschhorn综合症的关键区域(J:67077)。
Basic Information
(C57BL/6J x 129S4/SvJae)F1
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count