在将Gm114tm1Cpl杂合子(带有cre表达的)与含有一个loxP位点的实验鼠杂交后,去除了5和6号外显子,对应约950bp的编码序列。这导致在exon 7起始位置产生了一个终止密码子。尽管在睾丸中检测到了剪接产物,但western blot并未确认有含有C端末端的蛋白质表达。(来源:J:136802)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129
Targeted
插入,基因内删除
--
1
4
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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