在小鼠序列的exon 1中,有4个氨基酸被转换为人类对应的序列,并通过靶向同源重组,利用loxP引导的neo cassette插入到内含子1中。neo cassette可以通过与携带deleter cre表达的纯合品系杂交,或者通过暂时转染cre来移除。(来源:J:136269)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
核苷酸替换
--
1
3
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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