在第21外显子上游插入了loxP位点,然后在第22外显子下游插入了带有5' loxP位点的frt-flanked neo cassette。通过基因组的germ line中使用flp介导的重组,移除了neo cassette,使得第21和22外显子被标记为可剪接。来源:(J:136305)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count