The transgene is composed of a 1.9-kb rat AGT cDNA coupled to a 5.8-kb mouse alpha-MHC gene promoter. 1.6 kb of the rabbit bIVS2 intronic sequences are also included. RT-PCR analysis indeicated that this transgene was expressed specifically in the heart. 30 copies on the transgene are intergated in TG101 animals. (J:129140)